Welcome To The
GAWAD LAB

Studying Evolution at Cellular Resolution

Welcome to the Gawad lab! We work at the interface of biotechnology, computational biology, cellular biology, and clinical medicine. We take pride in our ability to think creatively to devise innovative solutions to challenging biological questions. We are focused on studying how the genomes of individual cells evolve when placed under selection pressure, and aim to understand how that genetic diversity contributes to human health and disease.

Clonal evolution

Cancer Clonal Evolution and Treatment Resistance

Cancer genome sequencing studies have shown clonal heterogeneity is the major cause of treatment resistance that ultimately causes cancer to recur. We are now studying the process of clonal evolution while patients are undergoing cancer treatment using single-cell sequencing methods we have developed in the lab. We aim to identify which cancer clonotypes are associated with resistance to specific drugs so we can better understand and predict treatment response.

Virulence

The Evolution and Virulence of Human Pathogens

Infectious diseases continue to be one of the major causes of early mortality worldwide. We are using single-cell sequencing methods we have developed to understand how more virulent pathogens emerge from a population of bacteria or viruses. We are also using these methods to more deeply understand how antibiotic resistance develops.

Novel tools

Development of Novel Genomics Tools

Although we have made tremendous progress in our ability to interrogate genomes in the past twenty years, we can still do better. We are continuously thinking about ways to improve how we measure genomic variation within a cell. We are also developing novel computational methods for modeling the evolution of populations of cells using single-cell sequencing data.

Software

Web applications and supporting material for research.

CellSeek

Developing Cerebellum

Cell Seek

Publications

A selection of recent publications and preprints.

Our Team

Charles Gawad

Charles Gawad

Lead Investigator

Veronica Gonzalez-Pena

Veronica Gonzalez-Pena

Research Scientist

Yakun Pang

Yakun Pang

Postdoctoral Fellow

Yuntao Xia

Yuntao Xia

Postdoctoral Fellow

David Klein

David Klein

Research Data Analyst

Lab Mascots

Ripley

Ripley

Tesla

Tesla

Lab Alumni

Name

Former Position

Date

Current Position

Current Location

Sivaraman Natarajan
Postdoctoral Fellow
2015-2019
Staff Scientist
St. Jude Children's Research Hospital
Rob Carter
Bioinformatics Scientist
2016-2019
Associate Director of Bioinformatics
ClariGene
Anju Cherian
Research Technologist
2019
Research Technologist
St. Jude Children's Research Hospital
Ousman Mahmud
Postdoctoral Fellow
2017-2018
Genomics Bioinformatician
IBM Watson Health
Yuki Inaba
Research Technologist
2017-2018
MD, PhD Student
University of Texas Southwestern
Morgan Carter
Pediatric Oncology Education Program
2016
Predoctoral Trainee
National Institutes of Health
Ian Nykaza
Pediatric Oncology Education Program
2017
Research Technologist
University of San Francisco (UCSF)
Sarah Youssef
MSc Student (Fullbright Scholar)
2016-2018
Clinical Pharmacist
57357 Pediatric Cancer Hospital
Greg Schwing
Pediatric Oncology Education Program
2015
MD, PhD Student
Wayne State University
Shelby Lane
Medical Student Researcher
2015
MD Student
University of Tennessee
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